The "Center for eHealth Applications and Services", as an autonomous organizational activity, was established in 2010 as the evolution of the eHealth research activity, founded in 1985 by Professor Stelios Orphanoudakis (1948-2005). The initial name of the Laboratory was “Center of Medical Informatics & Health Telematics Applications”.  Subsequent changes followed, leading to the former "Biomedical Informatics Laboratory". Since the beginning research and development (R&D) activities were focusing -among others- on Health Information Networks and advanced eHealth services.

Through its long research activities and participation in a large number of European research projects and international co-operations, the Center has developed a series of eHealth applications, which now are operating in a big number of healthcare organizations.

A major milestone was the implementation of HYGEIAnet which was the first Regional Health Telematics Network in Greece that involved all healthcare organizations of Crete as well as the local EKAB (National Health Emergency Coordination Center). Applications developed during that period are the predecessors of today’s eHealth services.

Another major milestone was the successful implementation of the Regional Health Information Networks for the 1st, 2nd, and 6th Regional Health System of Greece
 

Important milestones are the following:

• 1985
  Establishment of the Laboratory
• 2001
  Completion of the implementation of HYGEIAnet (first Regional Health Telematics Network in Greece)
• 2003
  eEurope Award for eHealth
• 2006
  Establishment of the Technical Support Office in Athens
• 2007
  *Certification with ISO 9001:2015 for Implementation of Information and Communication Technology projects in the domain of Health
  *Establishment of the Technical Support Office in Patras
• 2009
  Completion of the project "Integrated Health Information System and ICT Services for the 3rd Regional Health System of Attica" on behalf of Information Society SA (final beneficiary 2nd Regional Health System of Piraeus and Aegean)
• 2010
  Completion of the project "Implementation of the Integrated Health Information System for the 1st Regional Health System of Attica" on behalf of the 1st Regional Health System of Attica.
• 2011
  Certification of the Nursing and Medical Applications (under the product name ICS-M), which are part of the software suite “Integrated Care Solutions” with the Seal of Quality Electronic Health Record (EHR) Level 2 (EuroRec EHR Quality Seal Level 2) by the European Institute for Health Records EuroRec (www.eurorec.org).
• 2014
  Certification with ISO 27001:2013 for the implementation of ICT projects in the domain of health.
• 2016
  Τrademark registration for Integrated Care Solutions.
• 2017
  Completion of the project "Integrated Health Information System for the Regional Health and Welfare System of West Greece" on behalf of Information Society SA (final beneficiary 6nd Regional Health System of Peloponnese, Ionian Islands, Epirus and Western Greece)
• 2018
  Completion of the project "Integrated Health Information System for the 2nd Regional Health and Welfare System of South Aegean" on behalf of Information Society SA (final beneficiary 2nd Regional Health System of Piraeus and Aegean)
• 2019
  • Gold Healthcare Business Award for Integrated Care Solutions
  • 1st prize at Hacking Health Athens for Time is Brain
  • 1st Impact Award for Health Services Improvement at Athens Health Datathon for Medication Misuse in Old Age
  • High Impact Prize at ESMARTCITY Datathon
• 2020
  • FORTH 's ecosystem, through the Institute of Computer Science,  was distinguished as a 4 * Reference Site in the European Innovation Partnership in Active and Healthy Ageing
  • Special award from the group of mentors of the Economic Chamber of Greece (regional department of Eastern Crete) for the development of the business model of startup at the 3d Match & Develop a Startup Heraklion
  • Two awards for participating in BAYER 's Programs that Promote and Support innovation at the 3d Match & Develop a Startup Heraklion
  • Award for the best idea with a direct qualification in the 2nd Phase of the 11th Innovation & Technology Competition of NBG Business Seeds of the National Bank of Greece  at the 3d Match & Develop a Startup Heraklion
• 2021
  • Establishment of HDHC PC
  • IHE Conformance Integration Statement
  • Certification with ISO 27799:2016 for Information Security Management in Health
  • Winner of the 11th NBG Seeds Innovation & Technology Competition 
• 2022
  • Certification with ISO 13485:2016 for the quality system it applies for the services of design, development, supply, configuration and technical support services for software as medical device for IVD
  • IHE Conformance Integration Statement