The CHIC proposal aims at developing cutting edge ICT tools, services and secure infrastructure to foster the development of elaborate and reusable integrative models (hypermodels) and larger repositories so as to demonstrate benefits of having both the multiscale data and the correponding models readily available. Although the broader VPH domain is the primary target of the hypermodelling infrastructure to be developed by CHIC, the primary application domain will be cancer and in silico oncology. In the mid and long term CHIC aims to pave the way for reliable in silico clinical trials, lying at the heart of the vision of in silico medicine, and subsequently for patient individualized treatment optimization based on in silico experimentation.