The project aims to establish a comprehensive foundation for the development and application of ontologies within the context of food safety. It begins with a systematic review and documentation of the current state of the art in ontologies related to the food safety domain. The project also analyzes software tools suitable for ontology editing, management, and integration, and defines a governance model to support the sustainable development and maintenance of ontologies. Building on this groundwork, it identifies a range of case studies that illustrate how ontologies can be applied in various scenarios aligned with EFSA procedures. Two of these case studies are selected and implemented as proof-of-concept prototypes, demonstrating the practical value and applicability of ontological approaches in supporting data interoperability, traceability, and decision-making in the food safety domain.