Can ants perform inference? Gene Network Reconstruction using Swarm Intelligence
Speaker: Kyriakos Kentzoglanakis
Date: 04 June 2009 Time: 14:00-15:00
Location: "Mediterranean Studies" Seminar Room, FORTH. Heraklion, Crete
Host: Ioannis (Yanni) Tollis


The inverse problem is one of the most pressing challenges in Systems Biology today. The identification/reconstruction of gene regulatory networks from a variety of gene expression data sources is a complex task plagued, among others, by the curse of dimensionality, i.e. the striking insufficiency of observations in relation to the number of measured genes. This talk will introduce a model-based approach to reverse-engineering gene networks from gene expression time series, using a framework of swarm intelligence techniques, namely Ant Colony and Particle Swarm Optimization. Results on artificial and real-world gene networks will also be presented and discussed. The problem domain and methods used will be introduced so that no prior subject knowledge is required.


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