Information Systems Laboratory (ISL)
PROGNOCHIP - Development and Establishment of DNA Microarray Technology in Greece: Identification and Validation of Classification and Prognosis Molecular Markers for Breast Cancer
The completion of the Human Genome Project and the development of post-genomic applications have allowed new holistic approaches to disease analysis that will revolutionize biomedical research and health care. Consultation of both the comprehensive genotypic information of the patient and the detailed molecular classification of the disease will result in individualized treatments. The "Prognochip" project applies this approach in the field of breast cancer prognosis and treatment. In particular, it aims at: (i) the intelligent processing of microarray data, (ii) the classification of breast cancer profiles, (iii) the identification of candidate molecular markers, and (iv) the delivery of an Integrated Clinico-Genomics Environment to support the vision of individualized-medicine.
The building blocks of the Integrated Clinico-Genomics Environment include:
- a Clinical Information System to keep patients’ clinical information (i.e., clinical, laboratory, and histopathological information),
- a Genomic Information System to manage the specifications of the respective DNA microarray experiments (i.e., microarray design, hybridizations, etc.), analyze the raw hybridization data, and store the samples’ gene expression profiles,
- a middleware layer, called PrognoChip Mediator, that enables the seamless and efficient extraction of data from the various clinical and genomic sources, and
- a Data Mining layer, realized by a suite of data mining components and tools, that enables intelligent data processing and visualization.
Information regarding the activities of ISL in PROGNOCHIP are available on this site:
http://www.ics.forth.gr/isl/projects/PrognoChip/index.html
Contact Person: Anastasia Analyti, Dimitris Plexousakis
E Mail: {analyti, dp}ATics.forth.gr
Duration: 1/10/2003 - 30/9/2006 (36 months)
Funding: GSRT - Op. Pr. Competitiveness
Prime Contractor: FORTH - IMBB
Project Leader: Dimitrios Kafetzopoulos
Participants: Prolipsis A.E., University of Crete, IARC
